Immunology

The scientists in our immunology research group are leaders in the field of immunological discovery, working to provide health care professionals with therapies that target specific immunological diseases, using two major technology platforms: human monoclonal antibodies and small molecule kinase inhibitors. Our innovative approach has led to the development of human antibodies that affect important targets such as tumor necrosis factor-alpha (TNF-α) and interleukin-12 (IL-12) – proteins that play key roles in the inflammatory response underlying immunological diseases.

Our efforts in this field resulted in adalimumab, a fully human anti-TNF monoclonal antibody approved and being investigated for the treatment of several “autoimmune” diseases.

Making Sense of Monoclonal Antibodies

As highly targeted disease fighters, therapeutic monoclonal antibodies (mAbs) are revolutionizing the treatment of many illnesses. These work by engaging a patient’s own immune system or suppressing the immune system to combat disease.

 

As the protein TNF-α builds up in the joints, it leads to inflammation, which could ultimately result in damage to the tissue. Because of its role in the progression of inflammation, blocking the activity of TNF-α has become a key focus of biologic therapies, including adalimumab.	Adalimumab is a human monoclonal antibody, which means the immune system will recognize adalimumab as an antibody normally found in the body.	Adalimumab works by specifically targeting and binding to the TNF-α protein. This binding blocks the activity of TNF-α, which helps prevent inflammation.

 

Monoclonal Antibodies Defined

Antibodies are proteins produced by certain immune system cells called B-cells, which are the body’s defense against toxins, microbes and viruses. B-cells produce antibodies that bind to specific foreign molecules (or antigens) in the body. Monoclonal antibodies are designed to mimic the naturally occurring antibodies, which recognize and target particular antigens without damaging healthy cells and are reproduced in laboratories for use in combating disease.